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AZ7550 hydrochloride
CAS No. 2309762-40-9
AZ7550 hydrochloride ( AZ7550 hydrochloride (1421373-99-0 free base) )
产品货号. M26549 CAS No. 2309762-40-9
AZ7550 盐酸盐是 AZD9291 的活性代谢物，可抑制 IGF1R 的活性（IC50：1.6 μM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2082 | 有现货 |
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| 10MG | ￥3216 | 有现货 |
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| 25MG | ￥5370 | 有现货 |
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| 50MG | ￥7655 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AZ7550 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AZ7550 盐酸盐是 AZD9291 的活性代谢物，可抑制 IGF1R 的活性（IC50：1.6 μM）。
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产品描述AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).(In Vitro):AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM).
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体外实验AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively.
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体内实验——
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同义词AZ7550 hydrochloride (1421373-99-0 free base)
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通路Angiogenesis
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靶点EGFR
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受体Bacterial| GABAA| Human Endogenous Metabolite| Virus Protease
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研究领域——
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适应症——
化学信息
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CAS Number2309762-40-9
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分子量522.04
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分子式C27H32ClN7O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 1.88 mg/mL (3.60 mM)
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SMILESC=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)=O.[H]Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Yang H, et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Mol Pharmacol. 2016 Nov;90(5):530-539.
